Springer Netherlands PET for Drug Development and Evaluation
160.49 EUR
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Can drug development and evaluation be improved by the use of positron emission tomography (PET)? PET is now well established and many PET centres participate in networks that warrant the quality of their research. PET allows one to follow the effect of a drug on a variety of patients' metabolic parameters. In addition, PET may be used to follow the fate in vivo of a compound, allowing visualisation of its binding to specific receptors and a direct study of the mechanism of drug action in normal and pathological situations. The book shows the fields in which PET offers new and unique information for the development of drugs (conception, toxicity, pharmacokinetics and metabolism, clinical research, and relations between clinical and biological effects) and evaluates fields in which PET may shorten the development time of drugs. Audience: Professionals in the pharmaceutical industry in all areas of drug discovery and pharmacology, pre-clinical testing, pharmacokinetics and metabolism, clinical evaluation, registration and regulatory affairs. Government health authority representatives who assess data and documentation on new drug development and radiopharmaceuticals. Academic experts concerned with any of these areas.
EAN: 9780792337164
Versandkosten: 0 EUR
Verfügbarkeit: in stock
Lieferzeit: 3 bis 5 Werktage
Zustand: new
Can drug development and evaluation be improved by the use of positron emission tomography (PET)? PET is now well established and many PET centres participate in networks that warrant the quality of their research. PET allows one to follow the effect of a drug on a variety of patients' metabolic parameters. In addition, PET may be used to follow the fate in vivo of a compound, allowing visualisation of its binding to specific receptors and a direct study of the mechanism of drug action in normal and pathological situations. The book shows the fields in which PET offers new and unique information for the development of drugs (conception, toxicity, pharmacokinetics and metabolism, clinical research, and relations between clinical and biological effects) and evaluates fields in which PET may shorten the development time of drugs. Audience: Professionals in the pharmaceutical industry in all areas of drug discovery and pharmacology, pre-clinical testing, pharmacokinetics and metabolism, clinical evaluation, registration and regulatory affairs. Government health authority representatives who assess data and documentation on new drug development and radiopharmaceuticals. Academic experts concerned with any of these areas.
EAN: 9780792337164
Versandkosten: 0 EUR
Verfügbarkeit: in stock
Lieferzeit: 3 bis 5 Werktage
Zustand: new
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Springer Netherlands Evaluation and Assessment for Conservation
160.49 EUR
This book, previously published in hardback, has now been republished in paperback and added to the growing number of titles in Chapman & Hall's Conservation Biology Series. Evaluation and Assessment for Conservation contains pertinent examples and case studies from around the world illustrating the issues faced by conservationists. In addition, it summarizes a very large amount of material from the scientific literature.
Springer New York Cell-Based Assays Using iPSCs for Drug Development and Testing
123.04 EUR
The volume presents a variety of protocols that will be useful to researchers working in the field of disease modeling, drug discovery, and the cell biology of various tissues. Chapters in this book cover topics such as requirements and preconditions for using human induced pluripotent cell lines in assay development; the culture of iPSCs and iPSC-derived cardiomyocytes by bioreactor technologies; distinctions between hepatocytes, vascular endothelial cells, cardiomyocytes, renal podocytes, and neurons; and high content assays of mitochondrial function and autophagy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cell-Based Assay using iPSCs for Drug Development and Testing: Methods and Protocols is a valuable resource for researchers working in this important and developing field of study.
Springer Nature Switzerland Nanotechnologies for Drug Delivery and Biopharmaceutical Development
192.59 EUR
This book is a comprehensive coverage of the transformative role of nanotechnology in the field of biopharmaceuticals. The book covers the fundamental principles of nanotechnology and systematically explains how nanomaterials are revolutionizing drug delivery systems, formulation techniques, diagnostics, and imaging modalities. Through detailed discussions on lipid-based nanocarriers, polymeric nanoparticles, dendrimers, and nanogels, readers gain insights into the diverse array of nanomaterials and their applications in enhancing drug efficacy, targeting specific tissues, and minimizing adverse effects. Moreover, the book addresses critical aspects such as biocompatibility assessment, regulatory considerations, and ethical implications, underscoring the importance of responsible innovation in the development and commercialization of nano biopharmaceuticals. This book serves as an invaluable resource for researchers and practitioners to navigate the complex landscape of biopharmaceutical development. Through its interdisciplinary approach and forward-thinking perspectives on future trends and challenges, it contributes to shaping the future of healthcare by harnessing the power of nanotechnology to deliver innovative and effective therapeutics. The target audience for this book covers the fields of biopharmaceutical research, development, regulation, and policymaking. This includes scientists, researchers, and engineers seeking a deep understanding of nanotechnology's applications in drug delivery systems, formulation techniques, and diagnostic tools. Additionally, pharmaceutical industry professionals involved in drug development and manufacturing will find valuable insights into innovative nanoscale formulations and regulatory considerations. Overall, this book caters to a multidisciplinary audience seeking to leverage nanotechnologies for advancing biopharmaceutical research, development, and clinical practice.
Springer London Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development
85.59 EUR
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Springer Nature Singapore Preclinical cancer models for translational research and drug development
149.79 EUR
This book provides updated information on certain in vitro and preclinical in vivo cancer models. The topics covered include an update on advancements in the diagnosis, treatment and heterogeneity in certain cancers; the development of preclinical in vitro and xenograft-based in vivo cancer models as well as their validation based on widely accepted biomarkers; modelling of aberrations in bioenergetics in cancers. Also, the importance and latest advances of in silico modeling for the design of new and potent anti-cancer drugs has been reviewed. Cutting-edge and resourceful, this book is valuable for researchers, academicians, and professionals involved in cancer research.
Springer International Publishing Extremophilic Cyanobacteria For Novel Drug Development
53.49 EUR
This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria. It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs. The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activities.The second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as in silico techniques for rapid screening of secondary metabolites. Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs. Extremophilic Cyanobacteria For Novel Drug Development provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics.
Springer International Publishing Modeling, Control and Drug Development for COVID-19 Outbreak Prevention
246.09 EUR
This book is well-structured book which consists of 31 full chapters. The book chapters' deal with the recent research problems in the areas of modeling, control and drug development, and it presents various techniques of COVID-19 outbreak prevention modeling. The book also concentrates on computational simulations that may help speed up the development of drugs to counter the novel coronavirus responsible for COVID-19. This is an open access book.
Springer New York Cell-Based Assays Using iPSCs for Drug Development and Testing
171.19 EUR
The volume presents a variety of protocols that will be useful to researchers working in the field of disease modeling, drug discovery, and the cell biology of various tissues. Chapters in this book cover topics such as requirements and preconditions for using human induced pluripotent cell lines in assay development; the culture of iPSCs and iPSC-derived cardiomyocytes by bioreactor technologies; distinctions between hepatocytes, vascular endothelial cells, cardiomyocytes, renal podocytes, and neurons; and high content assays of mitochondrial function and autophagy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cell-Based Assay using iPSCs for Drug Development and Testing: Methods and Protocols is a valuable resource for researchers working in this important and developing field of study.